Department of Pediatrics, Nippon Medical School1）
|
|
| 1．Pulmonary Manifestations of Collagen Disease |
| Taiyo Imai, Yasuhiko Itoh1）, Yoshitaka Fukunaga1） |
| Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital Department of Pediatrics, Nippon Medical School1） |
|
| Abstract |
| Collagen-vascular disease（CVD）is a chronic systemic disease involving many organs including kidney, skin, brain and lung. Pulmonary involvement is relatively frequent and well known in adult patients. The majority of these patients develop pleural and/or pulmonary diseases at some time during the course of their illness. Even in children, pulmonary manifestations can be an initial complication of CVD as well as sometimes a life-threatening one. A number of pulmonary abnormalities has been investigated such as pleuritis with or without effusion, pneumonitis, alveolar hemorrhage, pulmonary hypertension, pulmonary/pleural fibrosis, and respiratory muscle myopathy. Although many radiological findings have been reported over several decades, the chest radiograph may occasionally be normal despite the presence of diffuse pulmonary impediment. Clinical studies of CT scans provide significant information leading to an early detection as well as serial observation of pulmonary involvement in CVD. Likewise, the introduction of high resolution CT（HRCT）allows us to demonstrate the smaller lesion that is not clearly identified by the conventional roentgenogram. HRCT may be proved to be of help in assessing disease progression, monitoring a response to therapy, and predicting a prognosis. In addition, cautious evaluation of pulmonary perfusion and/or ventilation scintigraphy is sometimes suggestive of underlying pulmonary involvement. |
| Keywords：Collagen-vascular disease（CVD），Pulmonary manifestation，Children，High Resolution CT（HRCT） |
|