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| 5．Broncho-Pulmonary Complications Associated with Graft-Versus-Host Disease after Stem-Cell Transplantation |
| Noriko Sato, Kiriko Tokuda1）, Takeji Matsushita |
Department of Pediatrics, International Medical Center of Japan
Department of Pediatrics, Ehime University1） |
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| Abstract |
Over the past two decades, stem cell transplantation has been increasingly used in the management of various hematological disorders and selected solid tumors. Pulmonary complications occur in approximately 40 to 60％ of patients after transplantation and affect overall survival. There are two different types according to the onset of various pulmonary complications : (1) early complications within the first 100 days after transplantation, (2) late complications occurring, more often encountered after that time interval.
Although progress has been made in the diagnosis and management of respiratory complications following transplantation, these are still frequently met and are a major cause of death. The use of DNA amplification and other diagnostic techniques has allowed an earlier detection of fungal and viral infections ; early antibiotic, antiviral and antifungal chemotherapy has improved survival in those patients.
We should be aware of the late-onset noninfectious complications, including bronchiolitis obliterans and BOOP(Bronchiolitis obliterans organizing pneumonia), which occur in 10 to 20％ following this procedure. |
| Keywords：Infectious complications, Non-infectious complications, Chronic GVHD, Bronchiolitis obliterans (BO) |
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