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Case Reports |
Tokyo Metropolitan Research Laboratory of Public Health1）
While epidemics of hepatitis A have not occurred recently in Japan, cases of hepatitis A are not infrequent. We should still pay attention to hepatitis A.
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| Hepatitis A Complicated by a Thickened Gallbladder Wall | |
| Yoshifusa Abe, Yuko Koyasu, Taeru Kitabayashi, Shuichiro Watanabe, Yasuhei Odajima, Kenji Sadamasu1）, Takayuki Shinkai1） | |
| Department of Pediatrics, Showa University School of Medicine Tokyo Metropolitan Research Laboratory of Public Health1） |
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| Abstract | |
| We describe a 9-year-old Japanese boy with hepatitis A. Acute hepatitis A in our patient was characterized by jaundice, an increase in AST and ALT, a positive serologic test for the IgM antibody to HAV, and negative serologic test for hepatitis B, C, infectious mononucleosis, cytomegalovirus infection, and mycoplasmal infection. Ultrasonography showed a thickened gallbladder wall without pericholecystic fluid in transverse projection. Computed tomography indicated a gallbladder wall of more than 10 mm thickness. Gallbladder wall thickening appears as a thin rim of enhancing mucosa, surrounded by a thicker zone of near-water attenuation, representing submucosal edema. We also studied a viral strain collected from a serum sample of our patient. The nucleotide variation within a 168 base region encoding the putative VP1/2A was not detected and the viral strain was classified as subgenotype IA. While epidemics of hepatitis A have not occurred recently in Japan, cases of hepatitis A are not infrequent. We should still pay attention to hepatitis A. |
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| Keywords：Hepatitis A, Genotype, Pediatric case, Epidemic, Thickened gallbladder wall | |
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