Preoperative Chemotherapy and Radiological Findings in a Patient with Huge Bilateral Nephroblastoma

Masahiro Hatanaka, Junko Yamagishi, Yuki Ishimaru, Kazunori Tahara
Yushi Otani, Hideo Nakai1), Miwako Nozaki2), Hitoshi Ikeda
Departments of Pediatric Surger y, Urology1),
and Radiology2),
Dokkyo Medical School Koshigaya Hospital

Abstract
　We present a patient with synchronous huge bilateral nephroblastoma, in whom treatment was begun with preoperative chemotherapy and followed by delayed tumor enucleation to preserve functioning renal tissue. During the preoperative chemotherapy, tumor response was obser ved by repeated CT and MRI. Radiological findings of the tumor were retrospectively examined and included changes in volume and images and the relationship with the renal parenchyma and the vessels in the hilum. The macroscopic and histologic findings of the excised tumors were also examined and compared with the radiological findings. We conclude that following a patient with radiological examinations is extremely important in determining the effectiveness of preoperative chemotherapy and the timing of delayed surgery.

Keywords：Nephroblastoma, Wilms'tumor, Bilateral tumor, Preoperative chemotherapy